Krypto the Super-Dog (Dwayne Johnson) and Superman (John Krasinski) are inseparable best friends, sharing the same superpowers and fighting crime in Metropolis side by side.
When Superman and the rest of the Justice League are kidnapped, Krypto must convince a rag-tag shelter pack—Ace the hound (Kevin Hart), PB the potbellied pig (Vanessa Bayer), Merton the turtle (Natasha Lyonne) and Chip the squirrel (Diego Luna)—to master their own newfound powers and help him rescue the superheroes.