Paul Atreides (Timothée Chalamet) continues his family's century-long journey to destroy the Emperor of the Known Universe. Crossing paths with Chani (Zendaya) and the Fremen, they team up on a warpath of revenge for Paul’s family.

Being the chosen one of the prophecy gifts, Paul can see into the future, which shows him an unimaginable and terrible fate on the horizon. With the knowledge of an upcoming war against the people that want him dead, including the evil Feyd-Rautha Harkonnen (Austin Butler), Paul and Chani have to strengthen their defences and win for their own people. Paul must do everything he can to prevent it, but will inevitably face the choice between the love of his life and the fate of the known universe.