Gru (voice of Steve Carell) and Lucy (voice of Kristen Wiig) and their girls —Margo, Edith and Agnes—welcome a new member to the Gru family, Gru Jr., who is intent on tormenting his dad.

Gru faces a new nemesis in Maxime Le Mal (voice of Will Ferrell) and his femme fatale girlfriend Valentina (voice of Sofia Vergara), and the family is forced to go on the run.