This live-action reimagining of Disney's 2002 animated classic follows the story of Stitch, a cute, fluffy alien who is programmed for destruction. After escaping captivity, Stitch crash-lands on Earth on the island of Hawaii. There, he comes across a lonely girl named Lilo (Maia Kealoha) and her sister Nani (Sydney Elizebeth Agudong), who are looking to adopt a dog.

Despite his destructive programming, through love, faith, and the ironclad belief in ohana (which means family), Lilo is able to help Stitch learn to care for someone else. The two become an inseparable pair who can take on anything together.

In pursuit are the mad scientist Jumba Jookiba (Zach Galifianakis) and his special agent partner Pleakley (Billy Magnussen), as well as the social worker Cobra Bubbles (Courtney B. Vance).